The effect of preceding respiratory viral infection towards bronchiolitis obliterans syndrome development in lung transplant recipients

Rasoul, H.D. Luijk, P. Zanen, F.M. Verduyn Lunel

Thursday 14 march 2019

13:21 - 13:23h at Tropentheater

Categories: Klinisch/Basaal, Parallelsessie

Parallel session: Parallelsessie XV – Basaal / Klinisch 2

Background: Lung transplant recipients are continuously exposed to respiratory viral infections. Bronchiolitis obliterans syndrome (BOS) is the major cause of morbidity and mortality post- transplantation. To identify if preceding (cumulative) respiratory viral infections contribute to BOS onset, a retrospective study of lung transplant recipients treated for ongoing care in the X centre and X hospital, from 2004 to 2013 was conducted. 

Methods: Approaches for modelling recurrent events are discussed. Secondly, the association between the first viral event and outcomes were assessed using Cox proportional hazards regression with time-dependent covariates.

Results: Results: 852 viral specimens were collected from 113 total patients with 81 patients producing 316 virus positive specimens in 285 episodes of community acquired respiratory viral infection. Overall, the risk of BOS was not elevated by viral infection (HR 1.33 [0.692, 2.57], p=0.387).

Conclusions: Conclusions: Respiratory viral infections occur in the majority of lung transplant recipients with and without BOS but was not associated with chronic rejection and mortality during the study period in this cohort.

Key words: Lung transplantation, bronchiolitis obliterans syndrome, Polymerase chain reaction, community acquired respiratory infections.